Cystic Fibrosis: Molecular Mechanisms and Diagnosis

Cystic Fibrosis: Molecular Mechanisms and Diagnosis Cystic fibrosis is a membrane transport disorder which is commonly affected in the autosomal recessive disease of white populations. It is also identified at birth by a certain condition called meconium ileus which means intestinal obstruction. In the advance stages, clinically it has been diagnosed by sticky viscous secretion of the pancreas and lungs (Gelehrter, 1998). Many years of direct research has failed to recognise the specific gene which is involved in cystic fibrosis (CF), although there are some various indirect research done which has indicated that there appeared an abnormality in the transport of ions during the process of cell membrane development. A very common diagnosis has been used to recognise this disease which is high increase of chloride content in sweat. Children suffering from this disorder develop pancreatic insufficiency which is usually treated with enzyme supplementation, antibiotics and physical treatments which are used to reduce the chest infection. Earlier the survival average is about 25 years. (Gelehrter, 1990). But in a recent study, it has been said that the life expectancy for cystic fibrosis patients has increased over the last 40 years. It has been necessary to identify the respiratory viruses in Cf to make the clinical decision to proceed with the necessary treatment. (cited in Wat, 2008). It is said that one can calculate approximately the frequency of heterozygous carriers would be about 1 in 25 individuals. There are various research works done on cultured cells and animal models to further study on the basic defects of the disease and find a successive treatment. (Hodson, M.E., 1995). HISTORY: From centuries the study and research of Cystic fibrosis has been done. Earlier people started diagnosing this condition in the newborns due to the salty taste in their skin. The survival rate was so low as six months. But as years followed, during the 1930s, a scientist named Guido fanconi had described the symstoms as gastrointestinal symdrone but latter named it as cystic fibrosis. The research had advanced when the cystic fibrosis gene was discovered following the study of mendels law researched by Gregor Mendel. The genetic knowledge on this particular disease was made more improving which indirectly improved the survival ascepts of CF patients. By 1980s, a deeper understanding of human genetics were developed. In 1989, two researchers had isolated the damaged gene in causing CF which was the main cause in affecting the chloride channel function. These were the channels which were helping in the movement of water and salt in the cell walls. Further study on this is making it pos sible to understand and find a treatment for this genetic disease. In recent years, various study via Gene theraphy has been helping various researches to fix the damaged gene. If this particular gene is fixed, the possible prevention, treatment and cure of CF would become a (Giddings,2009) Basic molecular genetics of Cf: In the year 1985, several groups were experimenting on gene therapy by linkage analysis, a linkage was observed on the chromosome 7, which in turn proceeded with testing some of the markers on chromosome 7 where they found CF gene near to these markers (met and J3.11). Techniques like physical mapping showed that the distance between these markers was approximately 1.6 million bp, which is as large for approximately 50 genes. Various interesting research were made in which it was found that a vast majority of chromosomes carrying the Cystic fibrosis mutation were also carrying a particular alleles for XV-2c and KM-19 which was further named as allele for XV-2c and + allele for KM-19. This type of hapotype (-/+) showed approximately in 25% of normal chromosomes, whereas rest showed other different patterns. A term was defined for this type of disease gene associated with a allele with the nearby markers, which was named as Linkage Disequilibrim. This term was made used to understand that these CF mutated genes were being descended from a common ancester. (Gelehrter, 1998) In a recent research, a genetic analysis was conducted by carefully cloning of a 500,000 bp candidate which resulted in three possible genes from the specific region which was studied. In testing under northern blotting technique it was found that this specific gene was coding for a 1480- amino acid protein including 26 exons with a length of 250,000 bp of DNA and the mRNA transcript was found to be 6129 bp long. In further studying a cloned and sequenced cDNA was prepared using the sweat glands of a Cf patient, it was found that there was a difference in exon 10 from a normal sequenced gene. There was a deletion in the 3 -bp found which might have caused the deletion of a single amino acid (phenylalanine) at the specificresidue 508. (Gelehrter, 1990). This type of mutation is known as Delta F508 or F508. Patients with homologous delta F508 mutation will tend to suffer with severe symptons of this disease, causing a very heavy loss of chloride ion transport.This causes an improper balance in the sodium and chloride ion ratio, eventually secreting a thin, mucus secretion in the lung area which traps bacteria, this causes severe lung infection, resulting a high mortality rate in CF patients. CFTR gene: This gene was initially cloned in 1989 in which it was mapped to human chromosome 7q21, with more interest in this particular region, researches were able to indentify 2 more closely linked markers other than (labelled MET and D758) which were D75122 and D75340, those were 10 kb part. Using lambda genomic DNA libraries, 280 kb of DNA were sequenced which were used to make long range restriction maps. These were also probed with cDNA clones to isolate a total of 500 kb. This can be seen in the figure By using various approaches like screening zoo blots, northern blots and cDNA libraries the genomic DNA clone was isolated. Four different regions were isolated, out of that, only one proved to be CF gene which was 6.5 kb sequence in length. Eventually, it was concluded that the CF gene controls the CFTR (cystic fibrosis transmembrane regulator) which encodes chloride channels which were responsible for the water transport on the plasma membrane of the epithelial cells which were connected to the lung airways. This mutation was causing the problem. Structure of the CFTR gene: After sequencing the CFTR gene, further study was done on it. The sequenced coding region of this gene showed a polypeptide molecular mass of 168138 daltons. The best site seen in this predicted protein was that it showed two repeated motifs, which showed some similarities to the nucleotide-binding domains (NBD) which is present in the membrane bounded protein. These membrane consisted in them six hydrophobic regions which composed 234 amino acids. Hydrophilic domains: These 2 hydrophilic domains contains approximately 150 amino acids in which some phenylalanine residue has been deleted at the region of the first NBD which shares similar homologies with the proteins which binds with the nucleotide. These two motifs are connected by a highly charged cytoplasmic domains referred as R- domain or regulatory domains. This domains encodes 13 exons that help in the phosphorylationby protein kinase K and rest helps in binding sites by protein kinase C. These domains and nucleotide binding folds in the binding sites suggest that hydrolysis is involved in the transportation of CFTR gene. CFTR Promoter: It was found out that CFTR gene had a addition promoter region with a size of 3.5 kb, later on, it led that these promoters showed the characteristics of housekeeping gene along with tissue specific functions. There were five reasons that were focused to show that the CFTR gene had these charactertics which were as follows: There were no TATA box element within the first 500 basepairs of the transcription sites. The GC content in the promoter region was high. There were addition multiple minor transcription sites identified along with the major transcription sites. Couple of SP1 sites were also identified. There was a very low expression of the CFTR gene found in the epithelium layer. Another conclusion was made that the CFTR gene might control transcription regulation. (prin mg, tho) Phenotypic function of the diseased gene: To understand the phenotype of the disease, it has been confirmed that an individual suffering must have two copies of a mutated Cystic fibrosis transmembrane conductance regulator (CFTR) gene to be expressed. It has also been understood that the development of this disease in different individuals varies due to differential influence by environmental and genetic factors. This various different forms of other genes can affect the phenotypes of the mutated gene of this disease.   MUTATED GENE: As it been understood that the most common mutated gene found in most cystic fibrosis defective gene is the delta F508. A detailed study about this gene was done in which it was found that CFTR protein helps in encoding single amino acid at position 508 on the chromosome 7. As this mutation affects the CFTR to perform its work in the cell and prevents it from locating itself in the cell membrane. Usually it is seen that, a newly synthesized CFTR protein adds itself to the missing chemical group by folding itself into appropriate shape which are escorted by their specific molecular chaperons to the surface of the cell. Because of the presence of this mutated CFTR gene, the imperfect CFTR binds onto the cell membrane which has a defect while opening and closing during regulating the chloride ion flow within the cell membrane. There are different mutated genes, in which some do not this synthesis or any modification or integratation into the membrane of the cell. Sometimes, these mutated genes fail to even respond to the signals within the cell that are responsible for the opening and closing of chloride flow. In some cases, the CFTR protein enters the cell membrane and also responds to the cell membrane but there would show a problem when the channel opens and there is improper flow of chloride ion out of the cell. Different mutations vary with different patients, patients with absent or very low CFTR protein in its cell membrane would cause severe disease causing depleting pancreatic functions. There are patients which have delta F508 mutation on both CFTR gene copies, this causes very poor pancreatic function which would secret high amount of mucus causing varying degrees of infection in the lungs. Another CFTR mutation namely R117H also develops a partial functioning CFTR protein, this mutation pairs w ith the severe mutated gene delta F508 causing the CF disease severe but varying in lung disease. It has been seen that some men who have been detected with this particular mutated gene R117H shows only one symptom of CF that is being Infertile which is due to lack of vas deferens. Inheritence of the CF gene: Diagnosing cystic fibrosis In most cases, cystic fibrosis is diagnosed by screening tests, which are carried out very early in life. However, some babies, children and even young adults have some unexplained illness in future so they are diagnosed later. There are four main ways of diagnosing cystic fibrosis: newborn testing antenatal testing carrier testing sweat testing Newborn Screening: In newborn screening there are two tests the first one is blood test in which small amount of blood is taken from the babys heel and transferred onto the card and it is examined in the laboratory for CF and it is also test inherited conditions, such as sickle cell anaemia and phenylketonuria.. Another test is genetic test in which saliva sample taken from the cheek and check whether a newborn has faulty CFTR genes. Antenatal testing: This test is done during the womens pregnancy to know that fatus has CF or not. There are following Amniocentesis: in it inserts a needle through abdominal wall into the uterus and take amniotic fluid surrounds the baby and tested in the laboratory Chorionic villus sampling: In it needle passed through the stomach into the womb sometimes a fine tube passed through the vagina into the neck of the uterus as an alternative. And take chorionic tissue which is a tiny piece of the developing placenta and these chromosomes which are in the cells of the tissue are examined in the laboratory for CFTR genes are normal or not. Both tests have risk of complication and also chance for miscarriage so it is offered only those mothers who have high risk of having child with the CF. Carrier testing: People who have two CFTR genes one is normal and another is faulty are CF carriers. So carriers pass faulty CFTR genes on to their children. This is simple test which is uses mouthwash to make sure that person is a carrier of cystic fibrosis. Swishing the mouthwash to collect the cells. And these containing cells are checked for the faulty gene. Sweat test: If blood and genetic tests have positive sign for CF so for confirmation sweat test diagnosis using This test measure the amount of salt in sweat. For that in one treatment room small area of skin on an arm or leg tested. Rub this skin with sweat producing chemical and then produce gentle electrical current with help of electrode it gives warm feeling .collect sweat on a pad or paper for analze. High levels of salt confirm diagnosis of CF. (180,205) Immunoreactive Trypsinogn: This analysis is used after sweat test if little sweat measured in newborns. Blood samples are taken after 2-3 days of birth and examined for immunoreactive trypsinogen (IRT) which is the increased levels of pancreatic enzyme. If IRT level is high then also it is not strong indicator of CF. Because infants with intestinal malformations and condition as bowel obstruction also have high level of enzyme which is for function of impair pancreatic. Lung X-rays and function tests: In the tests measure the amount of air the lungs can hold and how fast a person can breathe out to show how lungs add oxygen and remove carbon dioxide from the blood with the help of chest X-ray which show lung scarring from recurrent inflammation.This test do not confirm a diagnosis of CF but help in evaluating the severity of an individuals lung damage. Sinus X-ray: This test give signs of sinusitis, which indicates an infection and inflammation of nasal cavities. The X-ray shows the underlying cause becomes important for sinusitis. By cause of sinusitis is showing allergies and poorly functioning immune system. DNA mutation analysis: For highly specific result we used this technique for CF to look for the presence of many mutations in the CFTR gene. In it DNA isolated and purified from the blood sample or from a smear inside the cheek and for detect disease genes and indentify mutation within a specific DNA sequenced used micro array technology Sputum cultures: For this test, take a sample of your sputum (spit) to see what bacteria are growing in it. If there are bacteria called mucoid Pseudomonas, then it is advanced CF that needs aggressive treatment. (Giddings, 2009) TREATMENT In early years, there were no proper complete cure for cystic fibrosis . This has changed in recent years due to various researches done to treat CF which have been improved drastically. The aim for the treatment of cystic fibrosis are to Prevent infection in lungs,Remove the thick and sticky mucus from lungs, Prevent blockages in intestines and to Provide adequate nutrition.(http://www.nhlbi.nihHYPERLINK http://www.nhlbi.nih.gov/.gov/) Treatment for lung problems: It is essential to begin the treatment by reducing the infection and removing the thick and sticky mucus from the lungs. This can be done by performing the following lung treatment methods. CHEST PHYSICAL THERAPHY (CPT): This theraphy is also called percussion. CPT include pounding the chest and back over and over with the hands and a device that reduce the mucus layer from the lungs. Breathing techniques are also helpful to remove mucus from lungs. This techniques involve forcing out of some short or deeper breaths and following with a relaxed breath. The major purpose of this therapy for CF is to increase clearance of mucus and control infection in the lung and also to provide adequate nutrition and prevent intestinal blockage. MEDICINES: This is the primary treatment for the cystic fibrosis. Using medicines it helps in treating lung infection, decreases the swelling ,reduces the mucus and also opens the airways. The following types are the antibiotics used for cystic fibrosis treatment: Oral antibiotics are use to treat the lung infection. Inhaled antibiotics are used to control the infection caused by the pseudomonas bacteria. Intravenous medicines are used for control the severe infection. Anti-inflammatory medicines used to reduce swelling in airways. Drugs or steroids such as azithromycin, ibuprofen, prednisone and pentoxifylline are used to reduce inflammation. For the treatment of bacterial infection various lung antibiotics such as nebcin, tobrex, ciprofloxin, myambutol, biaxin, azactam are used Exercise: Aerobic exercise can help to reduce and clear the mucus from the airways. Regular exercise also enables to cut back on the CPT. Intracytoplasmic sperm injection is used to provide fertility for men with cystic fibrosis LUNG TRANSPLANTATION: Lung transplantion is a effective therapeutic option for the cystic-fibrosis patient. The successfully lung transplanted patients are able to control diabetic problems easily as the patients exercise capacity improves and the respiratory infection reduces.(Madden, 1992). In lung transplant ,the infected lung is replaced with a healthy lung by surgery. If CF is very advanced then lung transplantion is a good option. It is a major operation and sometimes also leads to some serious complications Oxygen Therapy: If oxygen level is very low in the blood then oxygen therapy is very effective(http://cystic-fibrosis.emedtv.com). NUTRITIONAL TREATMENT: C.F causes many digestive problems such as slow growth, pain, intestinal gas and severe. Nutritional treatment can improve the growth, development and strength of patient. It involves a balanced diet with low fat and high protein which make strong the patient to resist aganist some infection (http://www.healthscout.com). It contain pancreatic enzymes to digest protein and fat and absorbance of various vitamins. Nutriational therapy also contain supplements of different vitamins. The other treatment for digestive problems is medications for the treatment of intestinal blockages (http://www.nhlbi.nih.gov/). GENE THERAPY: Gene therapy involve transfer of DNA for therapeutic purpose. For the treatment of cystic fibrosis two approaches have been used. In the first approach, adenovirus was used as a vector, it has the epithelial cell lining. In this approach, adenovirus type-2 late promoter drives the CFTR gene. In the second approach, positively charged liposomes was used which can bind negatively charged DNA on its surface. These initial experiments have been used to change the electrical conductance of the nasal membrane. By these approaches a little correction of conductance abnormalities is possible. In the recent studies aerosol inhalers is used to saturate the upper part of the respiratory system. The reversal of the path physiology is possible if the correct form of CFTR gene is expressed. At present, retroviral-mediated gene transfer system is used for gene transfer for gene therapy of CF. Adenovirus is a suitable vector for gene transfer to the airway because it uses humans as a permissive host and it has a natural tropism for the lung .Liposome-mediated DNA transfer system is also used for gene transfer in gene therapy. Liposome is positively charged interact with DNA which is negatively charged and form lipid-coated DNA complex Different positively charged liposomes used to transfer the CFTR including DOTAP, DMRIE and DOTMA-DOPE. Several new treatments are developed to treat the CF. In one case, the sodium-channel inhibitor amiloride is insert to the airways of the patients which inhibit sodium absorption. The other possible approach is to allow to bypass the CFTR chloride channel and regulate other chloride channel present in the membrane of airways. The most effective way to treat the CF is to insert a new and normal copy of CFTR gene into the airway of respiratory tract of CF patients. RECENT ADVANCES: In recent years, various research works have improved the way to diagnose and treat cystic fibrosis. In the year 2006, it was published in the Science daily that certain scientists from Stanford University, USA were able to find out the basic defect causing CF. In which they had concluded that the airway blockage caused in CF was not caused due excessive fluid being reabsorbed within the glands but due to lack of fluid secretion from cystic fibrosis glands. (http://www.sciencedaily.com/releases/2006/03/060318232035.htm) In another research work done in the year 2008, certain scientist from USA were able to discover that a particular protein called CFTR were either missing or not present in the lungs of the CF patients which helps in fighting various bacteria like Pseudomonas aeruginosa when inhaled. Further studies are conducted to find the treatment through these proteins. (http://www.sciencedaily.com/releases/2008/09/080910210525.htm). In 2010, A team led by Professor Justin Hanes from John Hopkins university had researched on a mucus penetrating biodegradable nanoparticles which would help in delivery wide range of therapeutic molecules from small to various size of macromolecules to reduce the infection of lungs of the CF patients. In another research study done this year 2010, a team of researches were able to find out that a certain calcium- activated chloride channel were able to enable CF mucous cells to secrete normally which is required in the CFTR channel. So, it was concluded that drugs should be produces to enchance the ability of the calcium response which helps in activating the calcium activated chloride channels which are secreted in the CF cells. (http://www.sciencedaily.com/releases/2010/09/100917151848.htm)

Employment Among Peoples With Disabilities Social Work Essay

Employment Among Peoples With Disabilities Social Work Essay Companies decisions to hire and retain employee can be influence of variety of factors. The study examines factors that influence companies decision to hire a person with disabilities in Kota Kinabalu, Sabah. While not denying the fact that there are numerous factors contributing to the companies decisions to hire disabled people. According to the Department of Social Welfare Malaysia, persons with disability is any person who is unable to obtain for himself/herself, fully or partially, the normal requirements of an individual and / or is unable to participate fully in the community due to shortcomings either physically or mentally and whether it occurred since birth or later in life. There are six categories of disabilities that are identify and registered in the department that is first hearing disability including deaf and mute, second is vision disability including blind that is eyesight less than 3/60 for the good eye even with vision support equipment (eye glasses) and low visi on/partially sighted that is eyesight less 6/18 but equal or better than 3/60 for the good eye even with vision support equipment (eye glasses), third is physical disability such as Polio, Amputee, Muscular Dystrophy, Myopathy, Neuropathy, Osteogenesis Imperfecta and others, fourth is Cerebral Palsy such as Hemiplegia that is Cerebral palsy that affect half of the body, Diplegia that is Cerebral palsy that affect both legs and Quadriplegia that is Cerebral palsy that affect all limbs, fifth is learning disability that is Global Development Delay (for children age People with disabilities are often being socially excluded in our Malaysian Society (Malaysian Care Organisation). Negative attitudes towards persons with disabilities has been identified as a barrier them to particiapte fully in society (Hasnah Toran et al., 2009). Without a concerted effort and awareness from companies and public as well, there is no improvement for this people to participate fully in society. Malaysia passed the Person with Disability Act (PWDA) in 2008 as part of its obligations under the Convention on the Rights of Persons with Disabilities (UN convention). According to this Act, those persons with disabilities shall have equal access to public facilities, amenities, services and buildings, public transport, education, employment, information, communication and technology, cultural life, recreation, leisure and sport (www.thenutgraph.com). This Act as a basis for equalization of opportunities for person with disabilities, to eliminate discrimination and harrasment against them and to promote their full participation as equal citizens of this country (Zulfikri Osman, 2003). 1.1 PROBLEM STATEMENT There are 15,409 PWDs registered with the State Welfare Services Department in Kota Kinabalu, Sabah as at July 2010, including those with physical or mental disabilities, hearing and vision impairment, cerebral palsy as well as intellectually challenged according to Community Development and Consumer Affairs Minister Datuk Azizah Mohd Dun in the Daily Express( 10 October 2010). According to her, there are many other PWDs out there have not registered to the department and urges to do so and the society must adapt to their needs and accord them the same right. There are some approaches and campaign done by government to improve the standard of living disabled persons. In general, the reaction of the private sector towards employment of disabled people may be due to misperception about people with disabilities. Hooi (2000a, p. 4) quotes Bathmavathi Krishnan, a senior disabled librarian in Kuala Lumpur: Most employers are reluctant to employ the disabled because of concerns regarding safety regulations, the need to modify premises such as installing ramps, disabled-friendly toilets and extra medical costs. Mariah Abdul Rahman (Hooi 2000a, p. 4) a web-lab manager in MIMOS Bhd, cites prejudice and the fear of uncertainty among employers as the main reasons why people with disabilities find it difficult to seek employment. In this era of globalization and digitization where competitive pressures of the new economy spill over into the lives of the rich, poor and disabled people, the need for a decent job is even more fundamental to a life of dignified existence: The work that we do has a crucial impact on our social and material well-being, in terms of income, class, status, influence, social relationships and personal identity (Barnes, Mercer Shakespeare 1999, p.1 10). The purpose of this study is to investigate companies attitudes towards employment of persons with disabilities in Kota Kinabalu, Sabah . 1.2 RESEARCH OBJECTIVE 1) The objective of this study is to investigate factor that influence companies attitudes toward the employment of persons with disabilities. 2) To recommend suitable employee for the private company. 1.3 SCOPE OF STUDY The scope of the study covers a few selected Private companies in Kota Kinabalu, Sabah (Sembulan, Tanjung Aru, Lintas, Inanam and Likas). 1.4 SIGNIFICANT OF STUDY This study is significant because it seek to measure the companies opinions and view in hiring persons with disabilities. This study will benefit the government, disabled people, employers and local universities as there were few empirical studies in this area. Hence the findings from this study can be used by the government and employers to develop better effort in developing disabled people to live in better living conditions and in the workplace. 1.5 DEFINITION OF TERMS The terms used in the study are defined for ease of understanding 1.6.1 Disability person Those who have long term physical, mental, intellectual or sensory impairments which in interaction with various barriers may hinder their full and effective participation in society (Social Welfare Department of Malaysia). Disability is defined according to the American Disability Act: 1) A person who has a physical of mental impairment, which substantially limits a major life activity, 2) Has record of that impairment that is used by the employer to discriminate against the individual, and 3) Is regarded by others as having such an impairment, whether impaired or not (this category includes AIDS/HIV) (Fersh Thomas, 1993; Spechler, 1996; Presidents Committee on Employment of People with Disabilities, 1993). 1.6.2 Private Company Business firm in the private (non-public) sector of an economy, controlled and operated by private individuals (and not by civil servants or government-employees) (retrieved from businessdictionary on 18 October 2010). 1.6.3 Attitude` An attitude is a learned predisposition to behave in a consistent favorable or unfavorable way with respect to a given object (Schiffman Kanuk, 1994). Attitude is a combination of beliefs and feelings that influence behavior (Brostrand, 2006). author (Brostrand, 2006). While Triandis, Adampoulus, and Brinberg (1984) also defines attitude as an idea or belief is driven by feelings and produce a certain behavior in a social situation. CHAPTER 2 LITERATURE REVIEW Hiring People with Disabilities A 1994 study by Ford attempted to determine where employers received information about the ADA and their training in hiring people with disabilities. Participants were also asked what services they needed to employ people with severe disabilities and in what areas they were lacking information. Responses included lack of information about supported employment, disability, building modifications, employer benefits, laws, funding, rehabilitation technology devices and services, and service providers. When participants were asked whether they were able to provide the rehabilitation technology necessary to employ an individual with a disability, 74% said they were not. When asked to state why, 23% said lack of funds, 22% indicated lack of expertise, 19% did not know where to go for training, and 14% stated it was due to low priority, lack of time, lack of feedback, or personal constraints. Twenty-six percent of employers surveyed said they had never made a referral to a vocational rehabi litation agency for an employee with a disability. When asked why, 36% said they did not even know it was possible, 24% did not know where to refer to, 26% said it was not their job, and the remaining 14% stated it was not in their best interests or in the best interests of the employee with the disability (Ford, 13 1994). The results of this study indicate that employers need more information and assistance in employing people with disabilities. Employers Attitudes While some studies have explored the need employers have for information, other studies have investigated employers attitudes towards hiring people with disabilities. One study on employers attitudes made use of a scale developed by Kregel and Tomiyasu (1994) This scale measured the attitudes of 170 employers toward workers with disabilities and towards the ADA. The results of this study found that while 96% of the 170 employers interviewed knew of the ADA, only 36% said they would support mandated quotas for hiring people with disabilities. The employers were asked about their satisfaction and previous experience with people with disabilities in the workplace; 73% had previous experience. Of that 73%, 78% were satisfied with the performance of the worker with a disability, 11% were somewhat satisfied. Overall, this study found employers to have a positive attitude towards people with disabilities. The employers did acknowledge that in order for the transition into the workforce to be successful they needed to provide a good effort. On the other hand, employers did not feel they had to create jobs or employ persons with disabilities themselves. They did feel assistance would be necessary to hire a person with a disability, but few felt it would be too expensive. In addition, although these employers saw people with disabilities favorably, they believed the hiring of a person with a disability would depend on the extent or severity of the disability. The employers also expressed some personal concerns, which included fears of not being able to communicate with the employee and fear of the employee with a disability making special demands (Kregel Tomiyasu, 1994). Building Relationships Developing relationships between vocational rehabilitation agencies and employers will increase communication and benefit both. Employers will receive assistance in the logistics of hiring an individual with a disability and VR will more successfully place clients into open positions within those companies. Accommodation is one area where employers struggle to know what is necessary and how to implement it. When accommodating workers with disabilities it is important for companies to realize that they do not have to do it on their own. It is suggested that companies take a proactive approach. Some suggested guidelines are: 1) Designate a company representative to oversee ADA compliance. 2) Create and maintain cooperative relationships with other companies and community resources. 3) Ensure that all company policies are compatible with ADA prescriptions 4) Consult rehabilitation professionals to assist in the formulation and review of accommodation options, and preparation of work and non-work environments. (Mullins, Rumrill, Roessler, 1994, p. 16) Attitudes of Society and Employers Due to attitudes or society and, more specifically, employers, job placement and job development for individuals with a mental disability can be challenging in itself; add the concept of job development, and you have an even more complicated situation. In job placement, the job placement specialist works with individuals with mental illness in various types of vocational environments, finds out that they may be more like a salesperson attempting to sell a product to community employers. The product that the job placement specialist is promoting to community employers is his or her clients abilities and skills. The motivation for this action is that community employers have what rehabilitation professionals and their consumers want-a job in an integrated community setting. However, acquiring this vocational goal is not as easy as it sounds-get the job (University of Wisconsin-Stout, 1983). The placement to specialist needs to be persuasive, because if he or she is not able to promote their clients to employers in the community, the unemployment rate may stay the same or even worsen (Fabian Waterworth, 1993). In order for this event to take place, the job placement specialist must create a working relationship with the employer in order to create a positive working environment for his or her client. Malaysian empployers attitude A study by Zulfikri Osman (2003) on Malaysian employers attitudes toward hiring persons with disabilities found that Malaysian employers are found to be discriminative in hiring disabled workers. Jobs offered to disabled workers are normally for lower position. The Ministry of National Unity and Social Development thhrough its working group on legislation had drafted a proposed Act to be called Person with Disabilities Act. However, these federal initiatives, as important as they are, have not changed the way many employers feel about hiring the disabled people. The study also found that, those surveyed perceived their organizations had been unfair in offering jobs while at the same time do not provide special training programs tailored for disabled workers. On the positive side though, organizations gave the same benefits and salary schemes, equal opportunity for advancement and are socially responsible in term of employment oppotunity given to disabled workers. However, employers d o not really care about disabled people involvement in building. Moreover, organizations seemed to prefer normal prospective employees, during selection and recruitment, to disabled people. The cross tabulations revealed that the private sectors employment of disabled workers declined sharply. The three hypotheses were then tested and found that training and development policy and the legal and ethical environment were proven to have significant relationships with employers attitude individually. However, an organization unique workplace environment was not. Although the strengths of each relationship were not established the significance of two out of three, are thought to be good for future research and prediction on employers attitude. Finally, the findings raised the need for a review of existing legal provisions to ensure equal employment opportunity for all. A study by Noraini Mohd Salleh, Khalid Abdullah and Nor Aishah Buang (2001) on Job Opportunities for Special Needs Poplulation in Malaysia found that the special needs populations short comings or their handicapping factors were not the stumbling blocks of their career development and education has played a major role towards their success. Seven hundred fourthy six special needs individuals (blind, low vision, deaf, mentally retarded, cerebral palsy, down syndrome, epileptic, stutter, physically disabled, spastic, and with speech problems) with jobs were identified and some of the jobs undertaken by the special needs population are classified as: professional, semi-professional; skilled non-professional and unskilled non-professional. Hundred fourty government agencies and private companies were located. These employers or potential employers suggestions for their clients or potential clients training to be more specific and suitable for the job market; in line with the countrys nee ds; business bias; inclination towards industrialization: electronic, information technology; food and tailoring. A study by Prabha Ramakrishnan (2007) on Critical Factors Influencing Employment of Disabled Persons in Malaysia. There are four factors covered by the study that are namely, the organisational commitment to employment of disabled people, attitude attitude towards disabled workers, the organisational policies on disability, and the employment opportunities for the disabled people. The first three factors constitute the independent variables, and the last one, the dependent variable. The first variable organisational commitment to employment of disabled people. The second variable is attitude towards disabled workers. The third variable organisational policies on disability. Overall, these three independent variables significantly explain the variance in the dependent variable, i.e. employment opportunities for the disabled persons. The findings of this study show that the organisational commitment to the employment of disabled people is fairly favourable. This is indicated by a highe r organizational commitment by companies that employ disabled workers; it is also shown by a higher emphasis for training employees towards disability issues. However, there is no significant difference in the recruitment of disabled workers between organisations that employ no disabled persons and those that employ disabled persons. The overall attitude towards employment of disabled people is not actually favourable, although the co-workers perception of disabled staff is fairly favourable. While the organisational perception on the need for supervision of disabled employees is somewhat favourable, the organisations that currently employ disabled persons are of the opinion that greater supervision is needed. The general perception on the current organisational policy for employment of disabled persons is not really favourable, although organisations that employ disabled people perceive themselves to have a more favourable policy. Findings on the barriers to employment of disabled people indicate that Malaysian organisations perceive the lack of related experience in managing disability issues as the most significant barrier. Other barriers, in descending order, are the lack of education on disability topics, lack of required skill and training, cost of supervision of disabled workers, attitude towards and stereotyping of disabled workers, lack of knowledge about accommodation issues, cost of training for disabled employees, and the cost of accommodation for the disabled workers. Although the Malaysian government has provided incentives to the private sector and set quota for the public sector to improve the employment rate of disabled persons, overall research findings show that disability employment and opportunities for such employment is low in Malaysia. Ganapathy (Jayasooria 2000) in 1992 identified five reasons for low hiring of disabled persons in Malaysia; first reason is the absence of a nation-wide register of job seekers among disabled persons because the Government and voluntary agencies were not well coordinated, the second reason is the prejudice existing against disabled people, the third is the poor access to public facilities, the fourth reason is the restricted location of employment more concentrated than distributed, and, the fifth reason is reluctance of employers to modify or adapt machinery and facilities for disabled workers. 2.1 CONCEPTUAL FRAMEWORK Independent variables Dependent variable Co-workers perception Companies attitudes Work performance Managements perception on the need for supervision Figure 1 INDEPENDENT VARIABLES: Co-workers perception Co-workers perception towards disabled workers either favorably or non-favorably that affect on companies attitudes in hiring them. Work performance Work performance of disabled workers such as their skills and abilities in performing their task that affect on Companies attitudes. Managements perception on the need for supervision Managements perception on the need for supervision of disabled workers after hiring them that either favorably or non-favorably. DEPENDENT VARIABLE: COMPANIES ATTITUDES Companies attitude is referring to their opinions and views and what factors that influence them in hiring persons with disabilities. CHAPTER 3 RESEARCH METHOD 3.1 Research Design For the purpose of this study, the research design will be sample survey. The research demands for information from people in five places in Kota Kinabalu which are Sembulan, Likas and Tanjung Aru. It means the administration of questionnaires will be distributed to sample of selected company. Types of approaches being used is by a questionnaire survey. 3.2 Unit of Analysis As this study will address the companies attitudes towards employment persons with disabilities, unit analysis will be the employer and employee of the selected private companies. 3.3 Sample size The sample size for the purpose of this study is 50 respondents which taken randomly in that five places of selected private companies. 3.4 Sampling Technique Five places in selected area will be selected for closer analysis of companies attitudes towards employment of persons with disabilities. The type of sampling is random sampling technique to select the sample. The sampling frame for this study was produced by a compilation of names of corporations and smaller businesses from telephone directories and from the Labour Department List. A list of organisations was tabulated and a number was assigned to each organisation. The organisations were selected using the statistical random numbers table. 3.5 Research Measurement/instrument The variables and their measurement are outlined in the following sections. Co-workers perception Co-workers perception towards disabled workers either favorably or non-favorably that affect on companies attitudes in hiring them. It is interval scale; a set of statement can be developed to assess respondents perceptions. The respondents can agree or disagree using five-point Likert scale: strongly disagree= 1, disagree=2, neutral= 3, agree=4, strongly agree=5. Work performance Work performance of disabled workers such as their skills and abilities in performing their task that affect on Companies attitudes. The respondents can agree or disagree using five-point Likert scale: strongly disagree= 1, disagree=2, neutral= 3, agree=4, strongly agree=5. Managements perception on the need for supervision Managements perception on the need for supervision of disabled workers after hiring them that either favorably or non-favorably that affect on companies attitudes. strongly disagree= 1, disagree=2, neutral= 3, agree=4, strongly agree=5. 3.6 Data collection The data for this study will be collected thorough survey questionnaire. This method was chosen because it easier to deliver and collected. 3.7 Data Analysis For this study, data analysis was done by quantitative methods where statistical analysis was conducted in descriptive of statistic. Descriptive statistics methods were used to compute frequencies, measures of central tendency such as the mean, median and the mode and dispersion such as the range, the variance and the standard deviation. The data collected from the survey questionnaire were analysed using Statistical software tool (SPSS 17.0).

The Honorable Brutus in Shakespeares Julius Caesar :: Julius Caesar Essays

The Honorable Brutus in Shakespeare's Julius Caesar In Shakespeare's play of "Caesar" Brutus is a conspirator who portrays a person who favors a republic for Rome. Brutus is an honorable man. Many characters in the play show there reverence for Brutus. Brutus exemplifies his honor in many ways. Brutus is obsequious when he is needed to abet his fellow romans. Brutus is an honorable man. "Am I entreated to Speak and Strike? O Rome I make thee promise, If the redress will follow, then receivest thy full petition at the hand of Brutus" (Shakespeare 397). Brutus will obey to whatever the romans convey to him. Consequently, Brutus joins the conspiracy inorder to help the romans rid rome of Caesar. Brutus also understands that he is putting it all on the line for his romans, therefore Brutus is an honorable man. Brutus is a scrupulous man, whose virtues endure. "No not an oath, If not by the face of men, the sufferance of our souls, the time's abuse-If these motives be weak, break off betimes, and every men hence to his idle bed; So let high sighted tyranny rage on, till each man drop by lottery" (Shakespeare 399). Brutus said that if the conspirators do not join for a common cause, then there is no need for an oath because the conspirators are self-righteous, and they are serving the romans. If the conspirators don't bind together, then each man will go his own way, become a weakling, and die when it suits the tyrants caprice. Brutus is advocates peace, freedom and liberty, for all romans, which shows that Brutus is an altruistic as well as an honorable man. Brutus also had a compassion for Caesar when he had killed Caesar. "If then that a friend demand why Brutus rose against Caesar, this is my answer: Not that I loved Caesar less, but that I loved Rome more" (Shakespeare 421). Brutus had honored Caesar but Brutus felt that Caesar was to ambitious. Brutus also felt that Caesar made the romans as slaves.

Views on Colonialism in Donnes Elegy XIX and Wroths Sonnet 22 Essay

Views on Colonialism in Donne's Elegy XIX and Wroth's Sonnet 22 Introduction In the midst of Lady Mary Wroth's sonnet cycle, a sudden reference to the colonialist discoveries of dark skinned natives appears. Bringing to mind her participation in Jonson's "Masque of Blackness," she depicts dark-skinned Indians worshipping the sun as their god. In the midst of her ruminations on love and her preoccupations with her unfaithful lover, Amphilanthus, this sonnet touches on issues close to her personal life as well as some of the preoccupations of her era on the nature of colonialism. In particular the role of religion in England's colonialist efforts was of prime importance. An examination of John Donne's Elegy XIX, "To His Mistris Going to Bed" may give some insight into how Wroth's Sonnet 22, "Like to the Indians Scorched with the Sun" deals with the controversies surrounding imperialism. Historical Concerns Both authors had close personal ties to England's colonialist efforts in the New World. Lady Mary Wroth's uncle, Sir Philip Sydney, was an investor in Raleigh's attempted colony at Roanoke. This venture ultimately failed, however, and would later be followed under King James with the Virginia Company. John Donne was closely tied with the efforts following Raleigh's failed attempt. In 1608, after two failed attempts at securing a secretarial post, first in London and then in Ireland, "the report circulated that he sought to be made secretary of the colony, a position given instead to his friend William Strachey" (Johnson 127). If he had been awarded the position, he would have sailed with the new governor, Sir Thomas Gates. This was the ship that was shipwrecked in Bermuda and that winter the Jamestown colon... ...onne, John. "A Sermon vpon the VIII. Verse of the I. Chapter of the Acts of the Apostles" Greene, Thomas M. "The Poetics of Discovery: A Reading of Donne's Elegy 19." Yale Journal of Criticism. 2 (2) (1989): 129-143. Hester, M. Thomas. "Donne's (Re)Annunciation of the Virgin(ia Colony) in Elegy XIX." South Central Review: 49-63. Johnson, Stanley. "John Donne and the Virginia Company." ELH. 14 (2) (1947): 127-138. Raman, Shankar. "Can't Buy Me Love: Money Gender, and Colonialism in Donne's Erotic Verse." Criticism. 43 (2) (2001): 135-168. Roberts, Jospephine A. The Poems of Mary Wroth. Baton Rouge: Louisiana State University Press, 1983. Young, R. V. "'O my America, my new-found-land': Pornography and Imperial Politics in Donne's Elegies." Souch Central Review: 35-48. Warnke, Frank J. John Donne Poetry and Prose. New York: Random House, 1967.

My Philosophy on Teaching :: Education Teachers Learning Classroom Essays

My Philosophy on Teaching It became clear to me that I wanted to become an Elementary teacher when I was given the opportunity to attend Hinton Elementary School as a student volunteer to read to the first grade class during my junior year of High School. It was on this day that I realized that teaching is what I truly want to do with my life. Given the opportunity to read to the first graders and being able to get to know each of them filled a special place in my heart. After reading a few of my favorite childhood books to the first graders, I gave them the opportunity to read and sound out some of their favorite books to me. I am very grateful that I was given such an opportunity, such an eye opening experience – which helped me to realize that this is what I want to do with my life – Teach. Every teacher has an opinion as to what the best teaching method is. While each method has many advantages and disadvantages, I have chosen direct instruction as my main teaching method. To me, it seems to be more direct and easier to understand for elementary students. Direct teaching is also known as systematic, active, or explicit teaching. In this set, the teacher is a strong leader that develops, structures and teaches by having an academic focus point. With the emphasis on the importance of a structural lesson, the presentation of new information is followed be student practice and teacher feedback. A teacher must have a lot of patience with the younger children. It is often the case that students will fall behind because they have not yet mastered the basic skills of the given subject. With the direct teaching process, the children are able to receive several opportunities to enhance their learning and make them understand subjects more clearly. By refreshi ng their memories, using repetition, giving homework, and asking questions, a teacher can better understand the children and allow them to learn in a proper manner. The younger children can learn, remember and understand instead of just memorizing the information to get through a test and forgetting it after the test is over.

Diction, Imagery, Detail, and Syntax (DIDS) in Poetryâ€Worksheet Essay

Instructions: Analyze the text you selected and fill out the following worksheet in detail. Provide specific examples from the text that support your analysis. 1. Write the title of the text you have analyzed here: â€Å"When I Was Fair and Young† by Queen Elizabeth I circa 1585 2. List at least three examples of diction in the text that add to the overall tone. Explain how each word contributes to the emotional power of the piece. â€Å"Fair† and â€Å"Young† are good choices of words as it conveys o the audience that the Author was highly attractive. â€Å"Scorn† Conveys a strong negative emotion. it is stronger than using the word â€Å"dislike.† Importune is another word that conveys strong emotion; it is an urgent, persistent and intense request. â€Å"Fair† and â€Å"Young† Gives the poem a more soft and light tone which directly contrasted the intensity involved with the words â€Å"Scorn† and â€Å"Importune† 3. List at least three examples of imagery in the text that add to the overall tone. Explain how each description contributes to the emotional power of the piece. Fair and young gave a visualization of Queen Elizabeth I’s physical attributes when she was youthful. Scorn gives an image of a hard face and attitude, which again directly contrast the softer, gentler image of young and fair. With â€Å"weeping eyes† and â€Å"sighing hearts† I could see Elizabeth I’s rejected and dejected suitors. Where the author could have chosen more moderate, wild words, she used stronger words to communicate her severe emotions 4. List the examples of important details the author chose to include. Explain how these details contribute to the emotional power of the piece? Fair and young gives detail about her physical attributes and tells us why she was so lusted after; contributing an heartfelt emotion to the poem. How much men she severely brought to woe and despair by her scorn communicated a somewhat sorrowful emotion. 5. List the examples of important details the author chose to omit. Explain how these missing details contribute to the emotional power of the piece. The author did not include how her attitude changed after she was no longer fair, young and favored by grace to avoid impeding a moon present in the poem. Additionally, the author did not include how she was changed to no longer fair, young, and favored by grace; possibly to avoid impeding the mood too. 6. Analyze the author’s use of syntax in this text. Are the sentences long or short? Does the author use punctuation to slow down the pace, or short phrases to quicken it? Explain how the sentence structure contributes to the emotional power of the piece. The Sentences in the poem are medium. Her usage of punctuation and short phrases set a calm and consistent mood in the poem. 7. Select a tone (or multiple tones) from the list of Tone Words. Explain why this tone is the best way to describe this text. I say fatalistic, and ironic tones best fit the text. It was fatalistic for the author to see her haughty and prideful attitude ruin her beauty, and ironic, as pride comes before the fall (dramatic irony)

Indian Curries Essay

Indian curries are, with no doubt, a famous part of cuisine to be found almost everywhere around the world. They are popular for their great taste and wide variety. It is no wonder then to find restaurant and other forms of eateries specializing in Indian cuisine. An Indian cuisine is not complete without the curry. In fact, the word curry is synonymous with Indian cuisine. Apart from the variety and great taste of Indian curries, they also have tantalizing colors that are appealing to the eye. There is a misconception about the Indian curries that is held by the public, especially American public. Many people think that they are always spicy. This is not the case. Some curries have sour flavors, and even sweet in some cases. It is not true that curry powder is the only ingredient of curry food in India. There are other ingredients like pepper, chillies and others. However, it is true that spices are a central part of Indian curry dishes, but not the sole component. This paper is going briefly look at the historical background of Indian curry. The different types of Indian curries will also be analyzed. The writer will also analyze the incorporation of Indian curry in American cuisine, and the popularity of this curry amongst the American public. Indian Curries: A Brief Background When the word curry is used in the Indian context, it refers to sauce (Panjabi, 2006). As such, any kind of Indian food that is accompanied by a sauce is referred to as a curry. Curries in India are used as a side dish, meaning that they accompany other meals like rice, chicken or lamb (Sanmugam, 2003). On the other hand, curry powder is a combination of various spices. These will include turmeric, coriander and other powders like chillies and ginger. The term curry is derived from a word that is found in the southern Indian community of Tamil (Panjabi, 2006). This community used the word â€Å"kari† to describe the same kind of dish that Indians refer to as curry (Panjabi, 2006). Curries have a very long history in the Indian culture. By the year 3000 B. C. , most of the ingredients of curry powder were to be found in Indian farms (Raghavan, 2006). These include turmeric and pepper. Also, mustard and cardamom were to be found in these farms. It is important to note that these were the basic ingredients of curry powder, meaning that this powder existed that early in this civilization. But the earliest evidence of a recipe that can be described as curry dish appeared much later. This is the period around 1700 B. C (Raghavan, 2006). It was in form of a meat dish that was accompanied with a spicy sauce, the hall mark of Indian curry (Raghavan, 2006). This was found in Mesopotamia, and it was a recipe written on tablets. Archeologists and other analyst of the early civilizations contend that this dish was an offer to the Marduk God (Raghavan, 2006). Curry became a component of British cuisine in the late 18th century (Peterson, 2007). It was brought to this land by merchant ships sailing from India. The first recipe for what we refer to as â€Å"curry† today appeared in 1747 in Britain (Peterson, 2007). It was composed by Hannah Glasse. This was in her book â€Å"Glasse’s Art of Cookery† (Peterson, 2007). Before 1780, curry could be found in some restaurants in the city of London. Curry powder, the chief ingredient of curry dish in India, is made by combining at least a dozen spices. This combination is referred to by the Indians as garam masala (Hayden, 2009). This combination is used in the Indian curry dish to bring out the distinct flavor and taste that is associated with Indian cuisine, as well as to add to the tantalizing flavor. Early Indian curry dishes did not contain peppers. This is because peppers were not grown in India at that time. They only came to be incorporated into the dish after the Indians started trading with merchants who had access to red and chili peppers (Panjabi, 2006). Curry dish can be varied to cater for the need of vegetarians as well as the meat lovers. Types of Indian Curries  These are the type of curry dishes that can be found in restaurants of nowadays that specialize in Indian cuisine. The dishes, together with the accompanying recipe, originated from India and her environs, but are sometimes adapted to fit to the local environment. For example, beef is not used by Indians in their cuisines, as it is against the Hindu religion. However, one tends to find Indian curry accompanying beef in most contemporary restaurants in our society. Rogan Josh The chief ingredient of this curry dish is lamb (Panjabi, 2006). The spices in this dish are moderate. The dish has its roots in the cuisine that is practiced in the Kashmir. This is especially the northern region of this country (Panjabi, 2006). To spice it up, the chef uses conspicuous amounts of dried red chillies. This gives it its characteristic deep crimson color. Fresh tomatoes are also used. The tomatoes are accompanied by a dash of coriander. Jalfrezi This is another Indian curry dish that is moderately spiced, lacking the distinctive hot taste that many people like to associate with Indian cuisine (Hayden, 2009). The curry sauce is composed mainly of tomatoes. They are stir fried, then garnished with sweet pepper (Hayden, 2009). The individual can add more peppers to make the curry sauce hotter, instead of its original flavor of slightly sweet. This sauce can then accompany other dishes like fish with rice and bread. Vindaloo This dish will perhaps give the consumer the envisioned image of Indian curries. It is a very fiery curry that has conspicuous amounts of red peppers and vinegar (Hayden, 2009). This dish is not native to India. It came with the Portuguese who colonized this country. This was in the late 1400’s (Hayden, 2009). Originally, this dish was a combination of wine and garlic. Today, cardamom and mustard seeds can be used to add to the distinct hot taste of the sauce. Dopiaza These curry dish is based on onions. First, onions are browned. Then the chef will add ginger and garlic. These are the three main components of the sauce (Hayden, 2009). After this sauce is prepared, it is then combined with the beef, fish, chicken, lamb or any other kind of meat that the person desires. It is moderately dry. The above are just some of the common curry dishes that are to be found in our society. It is an indication of how Indian curries have influenced contemporary food preparation and habits in America. This can be gauged by the number of Indian restaurants that are to be found around the cities. Each city has at least three Indian restaurants (Raghavan, 2006). Though the dishes are of Indian origin, it is important to note that the restaurants serve both Indian and non-Indian clientele. Importance of Indian Curries Food serves a number of functions in the human society. It is not only used to satisfy the hunger pangs of the individual, but can also be out into a myriad of other many uses. For example, food can be used as a means of socialization, whereby people meet and socialize over a plate of food or a cup of tea. Food can also be used for cultural practices, for example when it is used by Indians as offerings to their gods. Indian curries serve these purposes and many others. However, the notable benefit of Indian curries is to be found in their use as medicinal agents. Indian curries have been known to fight common illnesses like Alzheimer and cancer. This is perhaps the reason why there are less cases of Alzheimer in India and her neighboring societies. For the curries to have the desired medicinal value, the chef is advised to use fresh ingredients, as opposed to the processed ingredients like curry powder found in many supermarket shelves today. Caraway seed is one of the oldest ingredients of Indian spices (Sanmugam, 2003). These seeds contain limonene oil (Sanmugam, 2003). This is very useful in boosting the individual’s immunity system. It also helps in soothing dry and itchy skin. This oil has been known to relieve many conditions, especially after been combined with olive oil. These include bronchitis and eye infections (Sanmugam, 2003). When used in food, this spice helps lactating mothers to produce more milk for the child. It can also be used to contain oral infections like halitosis. Cardamom pod is another very useful ingredient of Indian curry. It contains cineole (Peterson, 2007). This is a potent antioxidant. It boosts the immune system. It also detoxifies one’s liver. People who consume curry containing this spice regularly have been known to have reduced risks of getting cancer, especially stomach cancer (Peterson, 2007). It is also known to fight asthma and can be used to fight bad breath. Clove contains elements that are also of medicinal value. It has eugenol, another form of an antioxidant agent (Peterson, 2007). It relieves toothache and sore throat. Fennel seeds are also very helpful. They have antioxidant which helps in fighting infections like cancer. Anethole is one antioxidant contained in these seeds. Kaempferol and rutin are other antioxidants of the same seeds. Turmeric root contains curcuma. This is what gives it the signature orange taint. It is an antioxidant and a pain killer. Conclusion Indian curries have a very long history in the Indian civilization. The ingredients of curry powder were cultivated in this society three millennia before the birth of Christ. This is an indication that they were probably used in these times. Indian curries have greatly influenced the cuisine of contemporary western societies. This can be gauged by the profusion of Indian restaurants in the country. Indian curry can accompany a number of dishes, and the preparations and ingredients of this curry vary from one place to the other. Like any other form of food, Indian curry can be put into several uses apart from the conventional one of satisfying hunger. The writer noted the medicinal use of this curry, an indication of its popularity.